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Contents list for Molecular BioSystems, issue 1, 2009
Front cover
Mol. BioSyst., 2009, 5, 1
DOI: 10.1039/b821032m
Contents and Chemical Biology
Mol. BioSyst., 2009, 5, 3
DOI: 10.1039/b821033k
Editorial
Molecular BioSystems enters its fifth year!
Mol. BioSyst., 2009, 5, 13
DOI: 10.1039/b819258h
Molecular BioSystems has come a long way since its launch in 2005. As we celebrate its fifth year of publication we reflect on last year
s achievements and look forward to even greater things to come in 2009.
Profile
Meet the new members of the Editorial Board
Mol. BioSyst., 2009, 5, 16
DOI: 10.1039/b818119p
We welcome two new members to the Editorial Board of Molecular BioSystems this year: Professor Young-Tae Chang from the University of Singapore and Professor John Koh from the University of Delaware. Both are profiled in this article.
Opinion
The prospects of glycan biomarkers for the diagnosis of diseases
Carlito B. Lebrilla and Hyun Joo An,
Mol. BioSyst., 2009, 5, 17
DOI: 10.1039/b811781k
Enhanced HTML article available
Over 40 years of literature shows that glycosylation is greatly affected by diseases such as cancer. This opinion article argues that with glycans as disease markers there are several intrinsic advantages compared to other biomolecules, specifically proteins.
Review Articles
In search of small molecules blocking interactions between HIV proteins and intracellular cofactors
Katrien Busschots, Jan De Rijck, Frauke Christ and Zeger Debyser,
Mol. BioSyst., 2009, 5, 21
DOI: 10.1039/b810306b Enhanced HTML article available
By discussing the interaction between HIV-1 integrase and its cellular cofactor LEDGF/p75 we exemplify in this review the concept of the development of small molecule protein–protein interaction inhibitors as new antivirals.
Transposable elements as genomic diseases
Andreas Wagner,
Mol. BioSyst., 2009, 5, 32
DOI: 10.1039/b814624c Enhanced HTML article available
The evolutionary dynamics of transposable elements show many parallels to the epidemiology of human diseases.
SAC1 lipid phosphatase and growth control of the secretory pathway
Anastasia Blagoveshchenskaya and Peter Mayinger,
Mol. BioSyst., 2009, 5, 36
DOI: 10.1039/b810979f
This review focuses on SAC1 lipid phosphatase and how this enzyme operates in an evolutionary conserved mechanism to coordinate the secretory capacity of ER and Golgi during cell growth.
Papers
Crosstalk between G-protein and Ca2+ pathways switches intracellular cAMP levels
Najl V. Valeyev, Pat Heslop-Harrison, Ian Postlethwaite, Antonina N. Gizatullina, Nikolay V. Kotov and Declan G. Bates,
Mol. BioSyst., 2009, 5, 43
DOI: 10.1039/b807993e Enhanced HTML article available
A systems biology analysis of the Ca2+, cAMP and cGMP networks suggests an explanation for how the diversity of protein isoform combinations regulates a large variety of intracellular processes.
Asparagine 
-hydroxylation stabilizes the ankyrin repeat domain fold
Leanne Kelly, Michael A. McDonough, Mathew L. Coleman, Peter J. Ratcliffe and Christopher J. Schofield,
Mol. BioSyst., 2009, 5, 52
DOI: 10.1039/b815271c Enhanced HTML article available
Consensus ankyrin repeat domain proteins were shown to be substrates for an asparagine hydroxylase (factor inhibiting hypoxia inducible factor) and used to demonstrate that -hydroxylation of conserved asparagine residues stabilises the archetypical ankyrin repeat domain.
An integrated comparative phosphoproteomic and bioinformatic approach reveals a novel class of MPM-2 motifs upregulated in EGFRvIII-expressing glioblastoma cells
Brian A. Joughin, Kristen M. Naegle, Paul H. Huang, Michael B. Yaffe, Douglas A. Lauffenburger and Forest M. White,
Mol. BioSyst., 2009, 5, 59
DOI: 10.1039/b815075c Enhanced HTML article available
We demonstrate an experimental–bioinformatic method for identifying phosphorylated amino acid sequence motifs on phosphopeptides recognized by the MPM-2 antibody.
Mathematical model of the Lux luminescence system in the terrestrial bacterium Photorhabdus luminescens
Patricia A. Welham and Dov J. Stekel,
Mol. BioSyst., 2009, 5, 68
DOI: 10.1039/b812094c Enhanced HTML article available
A mathematical model of the Lux luminescence system, governed by the operon luxCDABE in the terrestrial bacterium Photorhabdus luminescens, was constructed. The model will have value in the interpretation of Lux Data.
The biosynthetic gene cluster of zorbamycin, a member of the bleomycin family of antitumor antibiotics, from Streptomyces flavoviridis ATCC 21892
Ute Galm, Evelyn Wendt-Pienkowski, Liyan Wang, Nicholas P. George, Tae-Jin Oh, Fan Yi, Meifeng Tao, Jane M. Coughlin and Ben Shen,
Mol. BioSyst., 2009, 5, 77
DOI: 10.1039/b814075h Enhanced HTML article available
The zorbamycin biosynthetic gene cluster was cloned, and a genetic system was developed to enable biosynthetic pathway manipulations in Streptomyces flavoviridis ATCC 21892.
Inhibitory effect of kinetin riboside in human heptamoa, HepG2
Jane Cheong, David Goh, Jean Wan Hong Yong, Swee Ngin Tan and Eng Shi Ong,
Mol. BioSyst., 2009, 5, 91
DOI: 10.1039/b712807j Enhanced HTML article available
In vitro growth inhibition of human hepatoma, HepG2 cells with kinetin riboside involved G2/M cell cycle arrest and cell death. LC/MSMS provided a rapid approach to study differentially expressed proteins in mitochondria induced in the HepG2 cells.
Back cover
Mol. BioSyst., 2009, 5, 99
DOI: 10.1039/b821035g
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