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Contents list for Molecular BioSystems, issue 12, 2008
Front cover
Mol. BioSyst., 2008, 4, 1141
DOI: 10.1039/b819139p
Inside front cover
Mol. BioSyst., 2008, 4, 1142
DOI: 10.1039/b819140a
Contents and Chemical Biology
Mol. BioSyst., 2008, 4, 1143
DOI: 10.1039/b819141g
Highlights
Molecular systems biology of ErbB1 signaling: bridging the gap through multiscale modeling and high-performance computing
Andrew J. Shih, Jeremy Purvis and Ravi Radhakrishnan,
Mol. BioSyst., 2008, 4, 1151
DOI: 10.1039/b803806f
Enhanced HTML article available
Molecular systems biology of ErbB1 receptor-mediated signaling: multiscale model treats processes with disparate length and time-scales in order to predict the effect of somatic mutations on signaling characteristics.
Stimulation of lung carcinoma cell growth by fibronectin–integrin signalling
Jeffrey D. Ritzenthaler, ShouWei Han and Jesse Roman,
Mol. BioSyst., 2008, 4, 1160
DOI: 10.1039/b800533h Enhanced HTML article available
We review the role of fibronectin–integrin signaling in the stimulation of lung carcinoma cell growth, one of the most common malignant tumors in the world.
Towards quantitative predictions in cell biology using chemical properties of proteins
Michele Vendruscolo and Gian Gaetano Tartaglia,
Mol. BioSyst., 2008, 4, 1170
DOI: 10.1039/b805710a Enhanced HTML article available
We discuss here how a link between the upper levels of in vivo abundances and critical concentrations of proteins offers an opportunity to make quantitative predictions in cell biology based on the chemical properties of proteins.
Structural dissection of the extracellular moieties of the type III secretion apparatus
Yu Wang, Lingling Zhang, Wendy L. Picking, William D. Picking and Roberto N. De Guzman,
Mol. BioSyst., 2008, 4, 1176
DOI: 10.1039/b808271p Enhanced HTML article available
Recently solved structures of the extracellular proteins of the type III secretion apparatus used by Gram-negative pathogens to inject virulence factors into their hosts have advanced our knowledge of the assembly and function of this bacterial nanoinjector.
Molecular mechanism of intestinal permeability: interaction at tight junctions
Zakir Hossain and Takashi Hirata,
Mol. BioSyst., 2008, 4, 1181
DOI: 10.1039/b800402a Enhanced HTML article available
The tight junction (TJ) is an essential component of the intestinal barrier. Occludin, claudin, junctional adhesion molecules, and the coxsackie virus and adenovirus receptor (CAR) are the major components of TJs. Polyunsaturated fatty acids may regulate occludin mRNA in TJs. CAR expression could be considered of possible clinical importance for application in gene therapy.
Specificity of protein lysine methyltransferases and methods for detection of lysine methylation of non-histone proteins
Philipp Rathert, Arunkumar Dhayalan, Huimin Ma and Albert Jeltsch,
Mol. BioSyst., 2008, 4, 1186
DOI: 10.1039/b811673c
Methylation of non-histone proteins appears to be a widespread biological signal for regulation of protein activity. SPOT peptide arrays have been introduced for specificity analysis of protein lysine methyltransferases and for the detection of new substrates of these enzymes.
Review Article
Droplet interface bilayers
Hagan Bayley, Brid Cronin, Andrew Heron, Matthew A. Holden, William L. Hwang, Ruhma Syeda, James Thompson and Mark Wallace,
Mol. BioSyst., 2008, 4, 1191
DOI: 10.1039/b808893d Enhanced HTML article available
Droplet interface bilayers (DIBs) provide a superior platform for the biophysical analysis of membrane proteins. The versatile DIBs can also form networks, with features that include built-in batteries and sensors. Scale bar = 1 mm.
Communication
Effective delivery of IgG-antibodies into infected cells via dendritic molecular transporter conjugate IgGMT
Sharon K. Hamilton, Mine R. Ikizler, Christian Wallen, Peter F. Wright and Eva Harth,
Mol. BioSyst., 2008, 4, 1209
DOI: 10.1039/b816645e Enhanced HTML article available
IgG antibody–transporter conjugates enable intracellular uptake of biologically active IgG antibodies that inhibit viral mediated syncytia formation in respiratory syncytial virus green fluorescent protein (RSV-GFP) infected human epithelial cells (HEp-2).
Paper
Fragile X mental retardation protein recognition of G quadruplex structure per se is sufficient for high affinity binding to RNA
Medhavi Bole, Lakshmi Menon and Mihaela-Rita Mihailescu,
Mol. BioSyst., 2008, 4, 1212
DOI: 10.1039/b812537f Enhanced HTML article available
Recognition of the RNA G quadruplex structure per se, in the absence of a stem region, is sufficient for fragile X mental retardation protein high affinity and specific binding.
Additions and corrections
Mol. BioSyst., 2008, 4, 1220
DOI: 10.1039/b819142p
Back matter
Mol. BioSyst., 2008, 4, 1221
DOI: 10.1039/b819156p
Back cover
Mol. BioSyst., 2008, 4, 1223
DOI: 10.1039/b819143n
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